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KMID : 0904020070230010001
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Journal of Korean Society for Vascular Surgery
2007 Volume.23 No. 1 p.1 ~ p.5
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Effect of Autologous Peripheral Blood Mononuclear Cell Transplantation on Patients with Chronic Ischemic Limb
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Lee Hayng-Ran
Kwon Oh-Jung
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Abstract
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Purpose: In the present study, the effects of autologous peripheral blood mononuclear cells (PBMNC) transplantation after granulocyte colony stimulation factor (G-CSF)-induced mobilization was investigated in patient with severe peripheral arterial disease.
Method: 4 cases were enrolled: 3 cases are atherosclerosis obliterance and 1 case is thromboangitis obliterance. Following administration of G-CSF (10?g/kg, maximum 600?g), 4 times for 4 days. PBMNC were harvest and injected via femoral artery to vascular foot bed.
Result: No serious complication was observed during G-CSF injection, harvest and injection. Improvement in the ankle brachial pressure index was seen in all patients at 4 weeks and ischemic ulcer improved in 2 of 3 patients. Using of pain control decreased in all cases and increased blood flow at 99 m-Tc perfusion scan in 2 of 2 patients.
Conclusion: These favorable outcomes strongly suggest a therapeutic impact of transplantation PBMNC in clinical setting.
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KEYWORD
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Peripheral blood mononuclear cell, Peripheral arterial disease
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